CanSaRCC Publications

Complete resection is critical in CIC-rearranged sarcomas (CRS). Chemotherapy benefit remains uncertain, underscoring the need for improved local control and novel, biology-driven therapies.

This is the largest series of EHE patients describing sequential systemic therapies. The role of systemic therapy in EHE in improving survival remains unclear and prospective studies with comparative arms are needed to add further insight into this chronic disease

Whole abdominal radiotherapy (WART) is utilized in children, adolescents, and young adults with intra-abdominal sarcoma, but efficacy and toxicity are uncertain. This study suggests WART is well tolerated among young sarcoma patients and provides meaningful local disease control when utilized in front-line adjuvant therapy.

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. Typically, treatment involves a multimodal approach. The long-term consequences of offering RT especially to the extremity in children can be significant including growth delay, contracture, arthritis, and secondary malignancy. By presenting this distinctive real-world data, our aim is to illustrate that in a select high volume pediatric sarcoma center, extremity RMS can potentially be effectively managed through surgery and chemotherapy alone.

Our real-world data show that TKIs have meaningful activity in recurrent BT with acceptable toxicities when started at modified dosing. Inclusion of TKIs in earlier lines of treatment and/or maintenance therapy could be questions for future research

Surgery is standard, and neoadjuvant chemotherapy (NACT) might be useful to downsize large lesions, especially in breast angiosarcoma (BAS) patients. Raising Radiation-induced sarcomas (RIS) awareness is fundamental to promoting appropriate management and fostering research through multi-institutional collaborations.

Osteosarcomas of the head and neck are rare and local recurrence remains a concern. Surgical resection with negative resection margins may improve survival, and a 3 mm resection margin threshold may optimize survival. Radiotherapy and/or chemotherapy should be considered in a multidisciplinary setting based on risk-features.

RIS is a serious late effect of radiotherapy in childhood cancer; however, radiation remains an integral component of primary tumor management and requires participation from a specialized multi-disciplinary team, aiming to mitigate RIS and other potential late effects.

EPP offers a feasible and life-prolonging surgical consideration for patients with locally advanced sarcoma involving the pleura in combination with chemotherapy and radiation. Consequently, EPP should be considered during multi-disciplinary tumor board discussions at high-volume centers.